Article
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.
Progress in retinal and eye research - 1 Mar 2010
Anderson Don H, Radeke Monte J, Gallo Natasha B, Chapin Ethan A, Johnson Patrick T, Curletti Christy R, Hancox Lisa S, Hu Jane, Ebright Jessica N, Malek Goldis, Hauser Michael A, Rickman Catherine Bowes, Bok Dean, Hageman Gregory S, Johnson Lincoln V
Abstract excerpt
During the past ten years, dramatic advances have been made in unraveling the biological bases of age-related macular degeneration (AMD), the most common cause of irreversible blindness in western populations. In that timeframe, two distinct lines of evidence emerged which implicated chronic local inflammation and activation of the complement cascade in AMD pathogenesis. First, a number of complement system...
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