Article
The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Feb 2011
Charbel Issa Peter, Chong N Victor, Scholl Hendrik P N
Abstract excerpt
BACKGROUND: Dysregulation of the complement system has been shown to play a major role in the pathogenesis of age-related macular degeneration (AMD). METHODS: The current evidence from human studies derives from immunohistochemical and proteomic studies in donor eyes, genetic association studies, and studies of blood complement protein levels. These lines of evidence are corroborated by in vitro and animal...
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