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Article

Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration

31 Jan 2019

Abstract excerpt

Abstract Age related macular degeneration (AMD) is the most common blinding disease in those over 60 years. In 50% of cases it is associated with polymorphisms of complement factor H (FH), implicating immune vulnerability. But such individuals may exhibit abnormal outer retinal blood flow decades before disease initiation, suggesting an early disease footprint. FH is expressed in the retinal pigmented epithelium...

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PMID: 30705315
DOI: 10.1038/s41598-018-37673-6

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