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Article

Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.

The American journal of pathology - 1 Jan 2015

Ding Jin-Dong, Kelly Una, Landowski Michael, Toomey Christopher B, Groelle Marybeth, Miller Chelsey, Smith Stephanie G, Klingeborn Mikael, Singhapricha Terry, Jiang Haixiang, Frank Michael M, Bowes Rickman Catherine

Abstract excerpt

Complement factor H (CFH) is an important regulatory protein in the alternative pathway of the complement system, and CFH polymorphisms increase the genetic risk of age-related macular degeneration dramatically. These same human CFH variants have also been associated with dense deposit disease. To mechanistically study the function of CFH in the pathogenesis of these diseases, we created transgenic mouse lines...

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Source

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Identifiers

PMID: 25447048
DOI: 10.1016/j.ajpath.2014.08.026
PMCID: PMC4278241

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.PMID 25447048Read ↗

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