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Article

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway

13 Aug 2021

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is a degenerative disease of the macula, where retinal pigment epithelium (RPE) cells are damaged in the early stages of the disease, and chronic inflammatory processes may be involved. Besides aging and lifestyle factors as drivers of AMD, a strong genetic association to AMD is found in genes of the complement system, with a...

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PMID: 34445430
DOI: 10.3390/ijms22168727

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CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB PathwayPMID 34445430Read ↗

<i>CFH</i> loss in human RPE cells leads to inflammation and complement system dysregulation <i>via</i> the NF-κB pathwaySemantic proximity Read ↗

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.Semantic proximity Read ↗

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cellsSemantic proximity Read ↗

CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complexSemantic proximity Read ↗

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular DegenerationSemantic proximity Read ↗

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