Article

<i>CFH</i> loss in human RPE cells leads to inflammation and complement system dysregulation <i>via</i> the NF-κB pathway

2021-04-19

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is a degenerative disease of the macula, where retinal pigment epithelium (RPE) cells are damaged in the early stages of the disease and chronic inflammatory processes may be involved. Besides ageing and lifestyle factors as drivers of AMD, a strong genetic association to AMD is found in genes of the complement system, with a...

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Literature Corpus work: d85c9707-ac83-5256-850c-0e17565c6e94
DOI: 10.1101/2021.04.19.440385

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