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Article

Retinal Changes Precede Visual Dysfunction in the Complement Factor H Knockout Mouse

2 Jul 2013

Abstract excerpt

We previously reported that aged mice lacking complement factor H (CFH) exhibit visual defects and structural changes in the retina. However, it is not known whether this phenotype is age-related or is the consequence of disturbed development. To address this question we investigated the effect of Cfh gene deletion on the retinal phenotype of young and mid-age mice. Cfh(-/-) mouse eyes exhibited thickening of the...

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PMID: 23844226
DOI: 10.1371/journal.pone.0068616

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