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Regulation of age-related macular degeneration-like pathology by complement factor H

19 May 2015

Abstract excerpt

Complement factor H (CFH) is a major susceptibility gene for age-related macular degeneration (AMD); however, its impact on AMD pathobiology is unresolved. Here, the role of CFH in the development of AMD pathology in vivo was interrogated by analyzing aged Cfh(+/-) and Cfh(-/-) mice fed a high-fat, cholesterol-enriched diet. Strikingly, decreased levels of CFH led to increased sub-retinal pigmented epithelium...

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Identifiers

PMID: 25991857
DOI: 10.1073/pnas.1424391112

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Regulation of age-related macular degeneration-like pathology by complement factor HPMID 25991857Read ↗

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