Article
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Aug 2012
Oulès Bénédicte, Del Prete Dolores, Greco Barbara, Zhang Xuexin, Lauritzen Inger, Sevalle Jean, Moreno Sebastien, Paterlini-Bréchot Patrizia, Trebak Mohamed, Checler Frédéric, Benfenati Fabio, Chami Mounia
Abstract excerpt
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca²⁺) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amyloid-β (Aβ) peptides. Here we investigate whether APP contributes to ER Ca²⁺ homeostasis and whether ER Ca²⁺ could in turn influence Aβ production. We show that...
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