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Article

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.

Cell calcium - 1 Sept 2011

Supnet Charlene, Bezprozvanny Ilya

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide and is at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD brain is thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline, an idea that underlies the 'amyloid hypothesis' of AD etiology in both the familal (FAD) and sporadic forms of the disease....

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Identifiers

PMID: 21663966
DOI: 10.1016/j.ceca.2011.05.013
PMCID: PMC3172403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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