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Article

The dysregulation of intracellular calcium in Alzheimer disease.

Cell calcium - 1 Feb 2010

Supnet Charlene, Bezprozvanny Ilya

Abstract excerpt

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is at present, incurable. The accumulation of toxic amyloid-beta (Abeta) peptide aggregates in AD brain are thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline, an idea that underlies the 'amyloid hypothesis' of AD etiology in both the familal (FAD) and sporadic forms of the disease....

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Identifiers

PMID: 20080301
DOI: 10.1016/j.ceca.2009.12.014
PMCID: PMC2834825

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Source receipt: pubmed, retrieved 7 Sept 2026.

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