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Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease

31 Mar 2021

Abstract excerpt

Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive neuronal cell loss. Recently, dysregulation of intracellular Ca2+homeostasis has been suggested as a common proximal cause of neural dysfunction in AD. Here, we investigated (1) the pathogenic role of destabilization of ryanodine receptor (RyR2) in endoplasmic reticulum (ER) upon development of AD phenotypes...

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Alzheimer's disease research and treatments
Cellular transport and secretion
Endoplasmic Reticulum Stress and Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33790404
DOI: 10.1038/s41598-021-86822-x

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