Article
Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.
Cell reports - 22 Sept 2020
Yao Jinjing, Sun Bo, Institoris Adam, Zhan Xiaoqin, Guo Wenting, Song Zhenpeng, Liu Yajing, Hiess Florian, Boyce Andrew K J, Ni Mingke, Wang Ruiwu, Ter Keurs Henk, Back Thomas G, Fill Michael, Thompson Roger J, Turner Ray W, Gordon Grant R, Chen S R Wayne
Abstract excerpt
Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine receptor 2 (RyR2) control of neuronal hyperactivity and AD progression. We show that a single RyR2 point mutation, E4872Q, which reduces RyR2 open time, prevents...
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