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Carvedilol suppresses ryanodine receptor-dependent Ca <sup>2+</sup> bursts in human neurons bearing <i>PSEN1</i> variants found in early onset Alzheimer’s disease

2023-09-16

Abstract excerpt

Seizures are increasingly being recognized as the hallmark of Alzheimer’s disease (AD). Neuronal hyperactivity can be a consequence of neuronal damage caused by abnormal amyloid β (Aß) depositions. However, it can also be a cell-autonomous phenomenon causing AD by Aß-independent mechanisms. Indeed, various studies using animal models showed that Ca 2+ releases from the endoplasmic reticulum (ER) via type 1 inosit...

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Literature Corpus work
483be6e8-0766-5238-bac4-302fd5571912
DOI
10.1101/2023.09.15.558029
Open publication

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Carvedilol suppresses ryanodine receptor-dependent Ca <sup>2+</sup> bursts in human neurons bearing <i>PSEN1</i> variants found in early onset Alzheimer’s diseaseDOI 10.1101/2023.09.15.558029
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