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Article

A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer's Disease Mouse Models by Upregulating Neuronal Autophagy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2023

Zhang Hua, Knight Caitlynn, Chen S R Wayne, Bezprozvanny Ilya

Abstract excerpt

It is well established that ryanodine receptors (RyanRs) are overactive in Alzheimer's disease (AD), and it has been suggested that inhibition of RyanR is potentially beneficial for AD treatment. In the present study, we explored a potential connection between basal RyanR activity and autophagy in neurons. Autophagy plays an important role in clearing damaged organelles and long-lived protein aggregates, and...

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Source

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Identifiers

PMID: 36627208
DOI: 10.1523/JNEUROSCI.1820-22.2022
PMCID: PMC9987572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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