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Article

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.

The Journal of biological chemistry - 16 Jun 2017

Bussiere Renaud, Lacampagne Alain, Reiken Steven, Liu Xiaoping, Scheuerman Valerie, Zalk Ran, Martin Cécile, Checler Frederic, Marks Andrew R, Chami Mounia

Abstract excerpt

Alteration of ryanodine receptor (RyR)-mediated calcium (Ca2+) signaling has been reported in Alzheimer disease (AD) models. However, the molecular mechanisms underlying altered RyR-mediated intracellular Ca2+ release in AD remain to be fully elucidated. We report here that RyR2 undergoes post-translational modifications (phosphorylation, oxidation, and nitrosylation) in SH-SY5Y neuroblastoma cells expressing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic AMP-Dependent Protein Kinases

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Share to Receptors, Adrenergic, beta-2

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Source

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Identifiers

PMID: 28476886
DOI: 10.1074/jbc.M116.743070
PMCID: PMC5473221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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