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Article

NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Sept 2010

Goussakov Ivan, Miller Megan B, Stutzmann Grace E

Abstract excerpt

Deficits in synaptic function, particularly through NMDA receptors (NMDARs), are linked to late-stage cognitive impairments in Alzheimer's disease (AD). At earlier disease stages, however, there is evidence for altered endoplasmic reticulum (ER) calcium signaling in human cases and in neurons from AD mouse models. Despite the fundamental importance of calcium to synaptic function, neither the extent of ER calcium...

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Identifiers

PMID: 20826675
DOI: 10.1523/JNEUROSCI.2474-10.2010
PMCID: PMC2944253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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