Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Sept 2010

Goussakov Ivan, Miller Megan B, Stutzmann Grace E

Abstract excerpt

Deficits in synaptic function, particularly through NMDA receptors (NMDARs), are linked to late-stage cognitive impairments in Alzheimer's disease (AD). At earlier disease stages, however, there is evidence for altered endoplasmic reticulum (ER) calcium signaling in human cases and in neurons fro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System Stimulants
Share to Excitatory Amino Acid Agonists
Share to Excitatory Amino Acid Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Excitatory Postsynaptic Potentials

Share to Heparin

Share to N-Methylaspartate

Share to Pyramidal Cells

Share to Transglutaminases

Source

Open in PubMed Open full text

Identifiers

PMID: 20826675
DOI: 10.1523/JNEUROSCI.2474-10.2010
PMCID: PMC2944253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20826675-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.PMID 20826675Read ↗

Mitochondrial Dysfunction in Alzheimer’s Disease Is Driven By Excess ER-Calcium Release in Patient-Derived NeuronsSemantic proximity Read ↗

A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer's Disease Mouse Models by Upregulating Neuronal Autophagy.Semantic proximity Read ↗

The dysregulation of intracellular calcium in Alzheimer disease.Semantic proximity Read ↗

ER calcium and Alzheimer's disease: in a state of flux.Semantic proximity Read ↗

Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.Semantic proximity Read ↗

Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease.Semantic proximity Read ↗

Calcium signaling and molecular mechanisms underlying neurodegenerative diseasesSemantic proximity Read ↗

Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s diseaseSemantic proximity Read ↗

Dysregulation of Intracellular Calcium Signaling in Alzheimer's DiseaseSemantic proximity Read ↗

Calcium dysregulation, IP3 signaling, and Alzheimer's disease.Semantic proximity Read ↗

Appearance of Amyloid-β Early in Life Initiates Neuronal Hyper-excitability, Mitochondrial Decay, and Loss of Dendritic Complexity in the Hippocampal CA1 Region of 5xFAD MiceSemantic proximity Read ↗

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.