Article
The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.
Neoplasia (New York, N.Y.) - 1 Jul 2012
Cattelani Sara, Ferrari-Amorotti Giovanna, Galavotti Sara, Defferrari Raffaella, Tanno Barbara, Cialfi Samantha, Vergalli Jenny, Fragliasso Valentina, Guerzoni Clara, Manzotti Gloria, Soliera Angela Rachele, Menin Chiara, Bertorelle Roberta, McDowell Heather P, Inserra Alessandro, Belli Maria Luisa, Varesio Luigi, Tweddle Deborah, Tonini Gian Paolo, Altavista Pierluigi, Dominici Carlo, Raschellà Giuseppe, Calabretta Bruno
Abstract excerpt
The p53 gene is rarely mutated in neuroblastoma, but codon 72 polymorphism that modulates its proapoptotic activity might influence cancer risk and clinical outcome. We investigated whether this polymorphism affects neuroblastoma risk and disease outcome and assessed the biologic effects of the p53-72R and p53-72P isoforms in p53-null cells. Comparison of 288 healthy subjects and 286 neuroblastoma patients...
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