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p53 Arg72Pro polymorphism predicts survival outcome in lung cancer patients in Indian population.

Cancer investigation - 1 Feb 2008

Sreeja Leelakumari, Syamala Vani, Raveendran Praveenkumar B, Santhi Sarojam, Madhavan Jayaprakash, Ankathil Ravindran

Abstract excerpt

In response to many forms of cellular stress, including DNA damage, the p53 protein functions to induce growth arrest, DNA repair, or apoptosis. Common allele variants in the TP53 gene modulate pathways of lung carcinogenesis and susceptibility to or prognosis of lung cancer. The prognostic role of the polymorphism was assessed in 422 subjects using PCR-RFLP. Logistic regression analysis showed a dominant...

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PMID: 18181044
DOI: 10.1080/07357900701638459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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