Article
A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models.
eLife - 20 Mar 2018
Zhao Yuhan, Wu Lihua, Yue Xuetian, Zhang Cen, Wang Jianming, Li Jun, Sun Xiaohui, Zhu Yiming, Feng Zhaohui, Hu Wenwei
Abstract excerpt
Tumor suppressor p53 prevents early death due to cancer development. However, the role of p53 in aging process and longevity has not been well-established. In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression. Here, employing a mouse model with knock-in of human...
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