Article
TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia.
Experimental oncology - 1 Dec 2014
Bilous N I, Abramenko I V, Chumak A A, Dyagil I S, Martіna Z V
Abstract excerpt
UNLABELLED: Defects in the tumor suppressor gene TP53 are known to be important in chronic lymphocytic leukemia (CLL) and TP53 inactivation is associated with a particularly aggressive form of the disease. The single nucleotide polymorphism in the TP53 gene at codon 72 (rs1042522), results in amino acid substitution influencing apoptotic potential of TP53 protein. The aim of the study was to evaluate the...
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