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Article

Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer.

The American journal of pathology - 1 Apr 2004

Schneider-Stock Regine, Mawrin Christian, Motsch Christiane, Boltze Carsten, Peters Brigitte, Hartig Roland, Buhtz Peter, Giers Anja, Rohrbeck Astrid, Freigang Bernd, Roessner Albert

Abstract excerpt

The allele constitution at codon 72 of the p53 gene (CGC-arginine or CCC-proline) plays a major role in inducing apoptosis in p53 mutant cells. To verify this, we determined GC-status, p53-mutations, and p53-loss of heterozygosity (LOH) in a group of 54 squamous cell carcinomas of the head and neck (SCCHN). A novel approach, using a one-step real-time PCR analysis with fluorescent hybridization probes, was...

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Identifiers

PMID: 15039212
DOI: 10.1016/S0002-9440(10)63211-7
PMCID: PMC1615339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer.PMID 15039212Read ↗

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