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Article

TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas.

Cancer genetics and cytogenetics - 1 Jan 2008

Lima-Ramos Vítor, Pacheco-Figueiredo Luís, Costa Sandra, Pardal Fernando, Silva Ana, Amorim Júlia, Lopes José Manuel, Reis Rui Manuel

Abstract excerpt

TP53 is a key tumor suppressor gene that encodes a transcriptional factor involved in several cellular mechanisms, including growth arrest, DNA repair, and induction of apoptosis. In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process. The Pro72 variant has been associated with a slower induction of apoptosis and may influence the risk of cancer...

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Identifiers

PMID: 18068527
DOI: 10.1016/j.cancergencyto.2007.08.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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