Article
In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.
BMC cancer - 18 Aug 2005
Sturm Isrid, Bosanquet Andrew G, Hummel Michael, Dörken Bernd, Daniel Peter T
Abstract excerpt
BACKGROUND: A common sequence polymorphism at codon 72 of the p53 gene encoding either arginine or proline was recently shown to be functionally relevant for apoptosis induction in vitro. In B-type chronic lymphocytic leukemia (B-CLL), p53 gene mutations occur in a subset of patients and are associated with impaired survival and drug resistance. Here, we address the functional relevance of the codon 72 single...
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