Article
The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2005
Hu Yingchuan, McDermott Michael P, Ahrendt Steven A
Abstract excerpt
The p53 gene plays a critical role in cell cycle control, the initiation of apoptosis, and in DNA repair. An Arg/Pro polymorphism at codon 72 of the p53 gene alters the ability of the p53 protein to induce apoptosis, influences the behavior of mutant p53, decreases DNA repair capacity, and may be linked with an increased risk of lung cancer. To further define the role of the p53 codon 72 polymorphism on DNA...
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