Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TP53 Pro72 allele potentially increases the poor prognostic significance of TP53 mutation in chronic lymphocytic leukemia.

Medical oncology (Northwood, London, England) - 1 Apr 2014

Dong Hua-Jie, Fang Cheng, Wang Li, Fan Lei, Xu Ji, Wu Jia-Zhu, Lu Ting-Xun, Li Jian-Yong, Xu Wei

Abstract excerpt

Previous studies have investigated the associations between TP53 mutations and codon 72 polymorphisms and prognosis in chronic lymphocytic leukemia (CLL). However, the joint effect of TP53 mutations and TP53 codon 72 polymorphisms on CLL prognosis remains uncertain. We used direct sequencing to detect TP53 mutations and codon 72 genotype in 207 patients with CLL. The Pro/Pro genotype was associated with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase 1
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunophenotyping

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Tumor Suppressor Protein p53

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 24615009
DOI: 10.1007/s12032-014-0908-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TP53 Pro72 allele potentially increases the poor prognostic significance of TP53 mutation in chronic lymphocytic leukemia.PMID 24615009Read ↗

TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia.Semantic proximity Read ↗

Clinical relevance of TP53 polymorphic genetic variations in chronic lymphocytic leukemia.Semantic proximity Read ↗

The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.Semantic proximity Read ↗

Two germ line polymorphisms of the tumour suppressor gene p53 may influence the biology of chronic lymphocytic leukaemia.Semantic proximity Read ↗

TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemiaSemantic proximity Read ↗

The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas.Semantic proximity Read ↗

p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis.Semantic proximity Read ↗

The Role of TP53 Gene Codon 72 Polymorphism in Leukemia: A PRISMA-Compliant Systematic Review and Meta-Analysis.Semantic proximity Read ↗

TP53 Arg72 as a favorable prognostic factor for Chinese diffuse large B-cell lymphoma patients treated with CHOP.Semantic proximity Read ↗

In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.Semantic proximity Read ↗

Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status.Semantic proximity Read ↗

The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.