Article
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
Cancer cell - 1 Apr 2003
Bergamaschi Daniele, Gasco Milena, Hiller Louise, Sullivan Alexandra, Syed Nelofer, Trigiante Giuseppe, Yulug Isik, Merlano Marco, Numico Gianmauro, Comino Alberto, Attard Marlene, Reelfs Olivier, Gusterson Barry, Bell Alexandra K, Heath Victoria, Tavassoli Mahvash, Farrell Paul J, Smith Paul, Lu Xin, Crook Tim
Abstract excerpt
Intact p73 function is shown to be an important determinant of cellular sensitivity to anticancer agents. Inhibition of p73 function by dominant-negative proteins or by mutant p53 abrogates apoptosis and cytotoxicity induced by these agents. A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers....
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