Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo.

Oncogene - 22 Apr 2004

Sullivan Alexandra, Syed Nelofer, Gasco Milena, Bergamaschi Daniele, Trigiante Giuseppe, Attard Marlene, Hiller Louise, Farrell Paul J, Smith Paul, Lu Xin, Crook Tim

Abstract excerpt

A single-nucleotide polymorphism (SNP) in exon 4 results in expression of either arginine (72R) or proline (72P) at codon 72 of p53. We demonstrate that the in vitro response of cells exposed to anticancer agents is strongly influenced by this SNP in wild-type p53. In inducible systems and in cel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Apoptosis
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15077186
DOI: 10.1038/sj.onc.1207428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15077186-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo.PMID 15077186Read ↗

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.Semantic proximity Read ↗

Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.Semantic proximity Read ↗

In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.Semantic proximity Read ↗

Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status.Semantic proximity Read ↗

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.Semantic proximity Read ↗

The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.Semantic proximity Read ↗

Role of p53 codon 72 arginine allele in cell survival in vitro and in the clinical outcome of patients with advanced breast cancer.Semantic proximity Read ↗

Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility.Semantic proximity Read ↗

p53 polymorphic variants at codon 72 exert different effects on cell cycle progression.Semantic proximity Read ↗

Mouse models for the p53 R72P polymorphism mimic human phenotypes.Semantic proximity Read ↗

The Codon 72 Polymorphism of p53 Regulates Interaction with NF-κB and Transactivation of Genes Involved in Immunity and InflammationSemantic proximity Read ↗

The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.