Article
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.
PLoS genetics - 1 Jan 2013
Manku Harinder, Langefeld Carl D, Guerra Sandra G, Malik Talat H, Alarcon-Riquelme Marta, Anaya Juan-Manuel, Bae Sang-Cheol, Boackle Susan A, Brown Elizabeth E, Criswell Lindsey A, Freedman Barry I, Gaffney Patrick M, Gregersen Peter A, Guthridge Joel M, Han Sang-Hoon, Harley John B, Jacob Chaim O, James Judith A, Kamen Diane L, Kaufman Kenneth M, Kelly Jennifer A, Martin Javier, Merrill Joan T, Moser Kathy L, Niewold Timothy B, Park So-Yeon, Pons-Estel Bernardo A, Sawalha Amr H, Scofield R Hal, Shen Nan, Stevens Anne M, Sun Celi, Gilkeson Gary S, Edberg Jeff C, Kimberly Robert P, Nath Swapan K, Tsao Betty P, Vyse Tim J
Abstract excerpt
We previously established an 80 kb haplotype upstream of TNFSF4 as a susceptibility locus in the autoimmune disease SLE. SLE-associated alleles at this locus are associated with inflammatory disorders, including atherosclerosis and ischaemic stroke. In Europeans, the TNFSF4 causal variants have remained elusive due to strong linkage disequilibrium exhibited by alleles spanning the region. Using a trans-ancestral...
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