Article
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.
American journal of human genetics - 6 Apr 2012
Lessard Christopher J, Adrianto Indra, Ice John A, Wiley Graham B, Kelly Jennifer A, Glenn Stuart B, Adler Adam J, Li He, Rasmussen Astrid, Williams Adrienne H, Ziegler Julie, Comeau Mary E, Marion Miranda, Wakeland Benjamin E, Liang Chaoying, Ramos Paula S, Grundahl Kiely M, Gallant Caroline J, Alarcón-Riquelme Marta E, Alarcón Graciela S, Anaya Juan-Manuel, Bae Sang-Cheol, Boackle Susan A, Brown Elizabeth E, Chang Deh-Ming, Cho Soo-Kyung, Criswell Lindsey A, Edberg Jeffrey C, Freedman Barry I, Gilkeson Gary S, Jacob Chaim O, James Judith A, Kamen Diane L, Kimberly Robert P, Kim Jae-Hoon, Martin Javier, Merrill Joan T, Niewold Timothy B, Park So-Yeon, Petri Michelle A, Pons-Estel Bernardo A, Ramsey-Goldman Rosalind, Reveille John D, Scofield R Hal, Song Yeong Wook, Stevens Anne M, Tsao Betty P, Vila Luis M, Vyse Timothy J, Yu Chack-Yung, Guthridge Joel M, Kaufman Kenneth M, Harley John B, Wakeland Edward K, Langefeld Carl D, Gaffney Patrick M, Montgomery Courtney G, Moser Kathy L
Abstract excerpt
Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disorder characterized by the loss of tolerance to self-antigens and dysregulated interferon responses. The etiology of SLE is complex, involving both heritable and environmental factors. Candidate-gene studies and genome-wi...
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