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Article

Direct evidence of allele-specific binding of CTCF and MeCP2 to Tsix in a HPRT-deficient female F₁ hybrid mouse cell line.

Cytogenetic and genome research - 1 Jan 2012

Son J, Min N Y, Choi J-H, Ko Y J, Liang W, Rhee S, Lee K-H

Abstract excerpt

Mammalian dosage compensation requires silencing of one of the two X chromosomes in females and is controlled by the X inactivation center (Xic). Xic contains many of the regulatory elements for the mutual interplay of X-inactive specific transcript (Xist) and Tsix, the antisense counterpart of X...

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Share to CCCTC-Binding Factor
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Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methyl-CpG-Binding Protein 2

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Source

Identifiers

PMID: 22889989
DOI: 10.1159/000341503

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22889989-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct evidence of allele-specific binding of CTCF and MeCP2 to Tsix in a HPRT-deficient female F₁ hybrid mouse cell line.PMID 22889989Read ↗

Nonrandom X chromosome inactivation is influenced by multiple regions on the murine X chromosome.Semantic proximity Read ↗

Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic.Semantic proximity Read ↗

Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.Semantic proximity Read ↗

Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.Semantic proximity Read ↗

NF-κB Signaling is Required for X-Chromosome Inactivation Maintenance Following T cell ActivationSemantic proximity Read ↗

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic miceSemantic proximity Read ↗

Understanding the X chromosome inactivation cycle in miceSemantic proximity Read ↗

A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation.Semantic proximity Read ↗

Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice.Semantic proximity Read ↗

Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line.Semantic proximity Read ↗

A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene TsxSemantic proximity Read ↗

YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing.Semantic proximity Read ↗

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