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Article

Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice.

Molecular and cellular biology - 1 Mar 2006

Boumil Rebecca Maxfield, Ogawa Yuya, Sun Bryan K, Huynh Khanh D, Lee Jeannie T

Abstract excerpt

During mammalian dosage compensation, one of two X-chromosomes in female cells is inactivated. The choice of which X is silenced can be imprinted or stochastic. Although genetic loci influencing the choice decision have been identified, the primary marks for imprinting and random selection remain undefined. Here, we examined the role of DNA methylation, a mechanism known to regulate imprinting in autosomal loci,...

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Identifiers

PMID: 16507990
DOI: 10.1128/MCB.26.6.2109-2117.2006
PMCID: PMC1430288

Genes

CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice.PMID 16507990Read ↗

Xite, X-inactivation intergenic transcription elements that regulate the probability of choice.Semantic proximity Read ↗

An ex vivo model for imprinting: mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation.Semantic proximity Read ↗

Whole-genome DNA methylomes of Tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulationSemantic proximity Read ↗

Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation.Semantic proximity Read ↗

The embryonic DNA methylation program modulates the <i>cis-</i> regulatory landscape via CTCF antagonismSemantic proximity Read ↗

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation.Semantic proximity Read ↗

A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation.Semantic proximity Read ↗

Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation.Semantic proximity Read ↗

Nonrandom X chromosome inactivation is influenced by multiple regions on the murine X chromosome.Semantic proximity Read ↗

A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.Semantic proximity Read ↗

The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.Semantic proximity Read ↗

Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist.Semantic proximity Read ↗

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