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Comparative structural insights and functional analysis for the distinct unbound states of Human AGO proteins

2024-03-25

Abstract excerpt

The four human Argonaute (AGO) proteins, essential in RNA interference and gene regulation, exhibit high sequence and structural similarity, yet differ functionally. Our molecular dynamics simulations revealed that while AGO proteins adopt similar open-close states, each one displays distinct local conformations, leading to unique interdomain distances and intramolecular interactions. We found that GW182/ZSWIM8 in...

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Literature Corpus work
1d993adf-95f1-55dd-b116-a66cc5b75874
DOI
10.21203/rs.3.rs-4058579/v1
Open publication

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Comparative structural insights and functional analysis for the distinct unbound states of Human AGO proteinsDOI 10.21203/rs.3.rs-4058579/v1
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