Article

Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target-silencing

2023-06-23

Abstract excerpt

The PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI-family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome integrity. Driven by this intensive host-pathogen arms race, piRNA pathway and its targeted transposons have co-evolved rapidly in a species-specific manner, but how the piRNA pathway specifically adapts to targe...

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Literature Corpus work: 11213a27-ecfb-5b55-8242-cec0f3d9c458
DOI: 10.1101/2023.06.23.546240

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