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Article

DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.

Molecular cell - 3 Dec 2004

Krishnan Vaidehi, Nirantar Saurabh, Crasta Karen, Cheng Alison Yi Hui, Surana Uttam

Abstract excerpt

The DNA replication checkpoint maintains replication fork integrity and prevents chromosome segregation during replication stresses. Mec1 and Rad53 (human ATM/ATR- and Chk2-like kinases, respectively) are critical effectors of this pathway in yeast. When treated with replication inhibitors, checkpoint-deficient mec1 or rad53 mutant fails to maintain replication fork integrity and proceeds to partition...

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Source

Identifiers

PMID: 15574325
DOI: 10.1016/j.molcel.2004.11.001

Genes

APC
ATM
ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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