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Article

Anaphase onset before complete DNA replication with intact checkpoint responses.

Science (New York, N.Y.) - 9 Mar 2007

Torres-Rosell Jordi, De Piccoli Giacomo, Cordon-Preciado Violeta, Farmer Sarah, Jarmuz Adam, Machin Felix, Pasero Philippe, Lisby Michael, Haber James E, Aragón Luis

Abstract excerpt

Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before mitosis is unknown. Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most significantly at natural replication-impeding loci like the ribosomal DNA gene cluster. In the absence of Smc5-Smc6,...

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Source

Identifiers

PMID: 17347440
DOI: 10.1126/science.1134025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Anaphase onset before complete DNA replication with intact checkpoint responses.PMID 17347440Read ↗

Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.Semantic proximity Read ↗

Smc5/6 is required for repair at collapsed replication forks.Semantic proximity Read ↗

DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.Semantic proximity Read ↗

CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis.Semantic proximity Read ↗

The yeast S phase checkpoint enables replicating chromosomes to bi-orient and restrain spindle extension during S phase distress.Semantic proximity Read ↗

Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery.Semantic proximity Read ↗

Cohesin association to replication sites depends on rad50 and promotes fork restart.Semantic proximity Read ↗

The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'.Semantic proximity Read ↗

DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

S-phase checkpoint activity and function throughout the cell cycleSemantic proximity Read ↗

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