Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.

Abstract excerpt

Twist1 has been demonstrated to play critical roles in the early development of neural crest and mesodermally derived tissues including the limb. Twist2 has been less well characterised but its relatively late onset of expression suggests specific roles in the development of a number of organs. Expression of Twist2 within the developing limbs begins after formation of the limb bud and persists within the...

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