Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.

Developmental biology - 1 Aug 2002

O'Rourke Meredith P, Soo Kenneth, Behringer Richard R, Hui Chi-Chung, Tam Patrick P L

Abstract excerpt

Loss of Twist gene function arrests the growth of the limb bud shortly after its formation. In the Twist(-/-) forelimb bud, Fgf10 expression is reduced, Fgf4 is not expressed, and the domain of Fgf8 and Fgfr2 expression is altered. This is accompanied by disruption of the expression of genes (Shh, Gli1, Gli2, Gli3, and Ptch) associated with SHH signalling in the limb bud mesenchyme, the down-regulation of Bmp4 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extremities
Share to Fibroblast Growth Factor 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 8

Share to In Situ Nick-End Labeling

Share to Polydactyly

Share to Receptor, Fibroblast Growth Factor, Type 2

Share to Receptors, Fibroblast Growth Factor

Share to Twist-Related Protein 1

Source

Identifiers

PMID: 12142027
DOI: 10.1006/dbio.2002.0730

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.PMID 12142027Read ↗

Twist functions in mouse development.Semantic proximity Read ↗

Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.Semantic proximity Read ↗

Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton.Semantic proximity Read ↗

Twist1 activity thresholds define multiple functions in limb development.Semantic proximity Read ↗

Timed deletion of Twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterning.Semantic proximity Read ↗

Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.Semantic proximity Read ↗

Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.Semantic proximity Read ↗

Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.Semantic proximity Read ↗

Methyltransferase G9A Regulates Osteogenesis via Twist Gene Repression.Semantic proximity Read ↗

Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice.Semantic proximity Read ↗

twist and snail as positive and negative regulators during Drosophila mesoderm development.Semantic proximity Read ↗

Tbx5 inhibits hedgehog signaling in determination of digit identity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.