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Article

An absence of Twist1 results in aberrant cardiac neural crest morphogenesis.

Developmental biology - 1 Aug 2008

Vincentz Joshua W, Barnes Ralston M, Rodgers Rhonda, Firulli Beth A, Conway Simon J, Firulli Anthony B

Abstract excerpt

The basic helix-loop-helix transcription factor Twist1 plays an essential role in mesenchymal cell populations during embryonic development and in pathological disease. Remodeling of the cardiac outflow tract (OFT) into the functionally separate aortic arch and pulmonary trunk is dependent upon the dynamic, coordinated contribution of multiple mesenchymal cell populations. Here, we report that Twist1(-/-) mice...

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Source

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Identifiers

PMID: 18539270
DOI: 10.1016/j.ydbio.2008.04.037
PMCID: PMC2572997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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