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Article

Twist1 activity thresholds define multiple functions in limb development.

Developmental biology - 1 Nov 2010

Krawchuk Dayana, Weiner Shoshana J, Chen You-Tzung, Lu Benson C, Costantini Frank, Behringer Richard R, Laufer Ed

Abstract excerpt

The basic helix-loop-helix transcription factor Twist1 is essential for normal limb development. Twist1(-/-) embryos die at midgestation. However, studies on early limb buds found that Twist1(-/-) mutant limb mesenchyme has an impaired response to FGF signaling from the apical ectodermal ridge, which disrupts the feedback loop between the mesenchyme and AER, and reduces and shifts anteriorly Shh expression in the...

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Identifiers

PMID: 20732316
DOI: 10.1016/j.ydbio.2010.08.015
PMCID: PMC2976588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Twist1 activity thresholds define multiple functions in limb development.PMID 20732316Read ↗

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