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Article

Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice.

The International journal of developmental biology - 1 Jan 2011

Guzzo Rosa M, Andreeva Viktoria, Spicer Douglas B, Drissi M Hicham

Abstract excerpt

Evidence from various in vitro gain and loss of function studies indicate that the bHLH transcription factor Twist1 negatively regulates chondrocyte differentiation; however limited information regarding Twist1 function in postnatal cartilage development and maintenance is available. Twist1 expression within the postnatal growth plate is restricted to immature, proliferating chondrocytes, and is significantly...

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Source

Identifiers

PMID: 21769775
DOI: 10.1387/ijdb.103274rg

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice.PMID 21769775Read ↗

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