Article
Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.
Developmental biology - 15 Jul 2002
Soo Kenneth, O'Rourke Meredith P, Khoo Poh-Lynn, Steiner Kirsten A, Wong Nicole, Behringer Richard R, Tam Patrick P L
Abstract excerpt
Loss of Twist function in the cranial mesenchyme of the mouse embryo causes failure of closure of the cephalic neural tube and malformation of the branchial arches. In the Twist(-/-) embryo, the expression of molecular markers that signify dorsal forebrain tissues is either absent or reduced, but those associated with ventral tissues display expanded domains of expression. Dorsoventral organization of the mid-...
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