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Article

Twist functions in mouse development.

The International journal of developmental biology - 1 Jan 2002

O'Rourke Meredith P, Tam Patrick P L

Abstract excerpt

The remarkable similarity in the profile of genetic activity and the frequent association of developmental defects of limb and craniofacial structures in mouse mutant and hereditary disorders point to the possibility that the development of the head and limb involves common morphogenetic mechanisms. Our recent studies on the impact of the loss of Twist function has highlighted the essential role of the basic...

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PMID: 12141426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Twist functions in mouse development.PMID 12141426Read ↗

Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.Semantic proximity Read ↗

Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.Semantic proximity Read ↗

Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton.Semantic proximity Read ↗

Timed deletion of Twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterning.Semantic proximity Read ↗

Twist1 activity thresholds define multiple functions in limb development.Semantic proximity Read ↗

Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.Semantic proximity Read ↗

Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.Semantic proximity Read ↗

twist and snail as positive and negative regulators during Drosophila mesoderm development.Semantic proximity Read ↗

Generation of a Twist1 conditional null allele in the mouse.Semantic proximity Read ↗

The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome.Semantic proximity Read ↗

Mutations of the TWIST gene in the Saethre-Chotzen syndrome.Semantic proximity Read ↗

Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.Semantic proximity Read ↗

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