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Article

Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton.

Developmental biology - 15 Feb 2012

Loebel David A F, Hor Angelyn C C, Bildsoe Heidi, Jones Vanessa, Chen You-Tzung, Behringer Richard R, Tam Patrick P L

Abstract excerpt

Development of the mouse forelimb bud depends on normal Twist1 activity. Global loss of Twist1 function before limb bud formation stops limb development and loss of Twist1 throughout the mesenchyme after limb bud initiation leads to polydactyly, the ulnarization or loss of the radius and malformations and reductions of the shoulder girdle. Here we show that conditional deletion of Twist1 by Mesp1-Cre in the...

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Identifiers

PMID: 22178153
DOI: 10.1016/j.ydbio.2011.11.020

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