Current insights into apolipoprotein E and the immune response in Alzheimer's disease.

doi:10.1111/imr.13414

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Article

Current insights into apolipoprotein E and the immune response in Alzheimer's disease.

Immunological reviews - 1 Oct 2024

Lin Peter Bor-Chian, Holtzman David M

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurological disorder and the most common cause of dementia. Genetic analyses identified apolipoprotein E (APOE) as the strongest genetic risk for late-onset AD. Studies have shown that ApoE modulates AD pathogenesis in part by influencing amyloid-β (Aβ) deposition. However, ApoE also appears to regulate elements of AD via regulation of innate immune response, especially...

Topics

Alzheimer Disease
Humans
Animals
Apolipoproteins E
Immunity, Innate
Amyloid beta-Peptides
Microglia
Astrocytes
T-Lymphocytes
Genetic Predisposition to Disease

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Identifiers

PMID: 39445515
DOI: 10.1111/imr.13414
PMCID: PMC11578782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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