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Article

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

10 Aug 2012

Abstract excerpt

De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome (MDS). Knockin mice expressing BAP1 with a...

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PMID: 22878500
DOI: 10.1126/science.1221711

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Related research

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Research trail→

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Loss of the Tumor Suppressor BAP1 Causes Myeloid TransformationPMID 22878500Read ↗

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The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.Semantic proximity Read ↗

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice.Semantic proximity Read ↗

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Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.Semantic proximity Read ↗

Dysregulated expression of <i>Hoxa1</i> isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromesSemantic proximity Read ↗

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