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Article

BAP1 in cancer: epigenetic stability and genome integrity

1 Nov 2022

Abstract excerpt

Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven mesothelioma, thus BAP1 status has been postulated to participate in gene-environment interaction. Intriguingly, BAP1 functions display also a high degree of tissue...

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PMID: 36318367
DOI: 10.1007/s12672-022-00579-x

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