Article
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nature communications - 16 Jul 2018
Asada Shuhei, Goyama Susumu, Inoue Daichi, Shikata Shiori, Takeda Reina, Fukushima Tsuyoshi, Yonezawa Taishi, Fujino Takeshi, Hayashi Yasutaka, Kawabata Kimihito Cojin, Fukuyama Tomofusa, Tanaka Yosuke, Yokoyama Akihiko, Yamazaki Satoshi, Kozuka-Hata Hiroko, Oyama Masaaki, Kojima Shinya, Kawazu Masahito, Mano Hiroyuki, Kitamura Toshio
Abstract excerpt
ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of mutant ASXL1 (ASXL1-MT) and BAP1 in promoting myeloid leukaemogenesis. BAP1 expression results in increased monoubiquitination of ASXL1-MT,...
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