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BAP1: Not just a BRCA1-associated protein

19 Aug 2020

Abstract excerpt

BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of processes including DNA damage repair, cell cycle control, chromatin modification, programmed cell death, and the immune response. Mutations in the BAP1 gene commonly result in a number of aggressive cancers; predominantly...

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PMID: 32877777
DOI: 10.1016/j.ctrv.2020.102091

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