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Article

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.

Nature genetics - 5 Jun 2011

Bott Matthew, Brevet Marie, Taylor Barry S, Shimizu Shigeki, Ito Tatsuo, Wang Lu, Creaney Jenette, Lake Richard A, Zakowski Maureen F, Reva Boris, Sander Chris, Delsite Robert, Powell Simon, Zhou Qin, Shen Ronglai, Olshen Adam, Rusch Valerie, Ladanyi Marc

Abstract excerpt

Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation, but other highly recurrent mutations have not been described. To identify additional driver genes, we used an integrated genomic analysis of 53 MPM tumor samples to guide a focused sequencing effort that uncovered somatic inactivating mutations in BAP1 in 23% of MPMs. The BAP1 nuclear deubiquitinase is known to target histones...

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Share to Chromosomes, Human, Pair 3
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21642991
DOI: 10.1038/ng.855
PMCID: PMC4643098

Genes

BAP1
ASXL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.PMID 21642991Read ↗

Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.Semantic proximity Read ↗

New strategies in pleural mesothelioma: BAP1 and NF2 as novel targets for therapeutic development and risk assessment.Semantic proximity Read ↗

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.Semantic proximity Read ↗

BAP1 Loss Predicts Therapeutic Vulnerability in Malignant Peritoneal MesotheliomaSemantic proximity Read ↗

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in CancerSemantic proximity Read ↗

BAP1: Not just a BRCA1-associated proteinSemantic proximity Read ↗

Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitorsSemantic proximity Read ↗

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BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma.Semantic proximity Read ↗

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in miceSemantic proximity Read ↗

Isolated <i>BAP1</i> loss in malignant pleural mesothelioma predicts immunogenicity with implications for immunotherapeutic responseSemantic proximity Read ↗

Loss of the Tumor Suppressor BAP1 Causes Myeloid TransformationSemantic proximity Read ↗

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